Hemophilia Treatment Risks

The only effective treatment available for hemophilia today is replacement therapy. What is replacement therapy? To understand the cure one should first understand the cause. Hemophilia is an inherited condition caused by the presence of an extra X chromosome and this X chromosome stops the blood or reduces the body's ability to stop the bleeding. In normal people blood should clot and that is how bleeding is stopped and this is caused due to the natural reaction of the body.

When it comes to treating the condition the replacement therapy replaces the gene that is missing and causes clotting in the body. The main factors for hemophilia are factor VIII and Factor IX. Replacement therapy can help the body to stop bleeding and help clotting.

Hemophiliac condition varies from person to person and in some people it is mild and some people it is moderate and in some it is a severe condition. Even though the treatment is effective, it can be risky in many counts like it can cause damage to joints and muscles. There can be damage caused to the other parts of the body due to the delay in treatment of hemophilic condition. The treatments involve inducing a genetic factor that causes clotting in the body and this is called the ant hemophilic factor. This treatment has also recently been approved by the FDA. The side effects of this process have not been explored still and there may be other complications if an anti hemophilic agent is induced into the body.

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Hemophilia Disease And Cells & Blood Clot Problems

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Hemophilia - Orthodox Medicine

Thrombosis, the process of blood and non blood clotting that can be normal and abnormal as in the case of atherosclerotic emboli that will cause thrombi, small circulatory clots closing a minor artery-capillary of the circulatory system and resulting in a local infarct.

The most common and widely known historic blood disorder (in humans), a condition in which the ability to clot in blood is highly and severely reduced for a couple of reasons caused by a hereditary genuine lack of the coagulation clotting factor viii, causing the affected patient and sufferer to bleed extremely and severely from the very slight injury, leaving the patient's body full of bluish bruises due to under skin bleedings and is usually typical at the legs.

Two types of the disease are known:

- Hemophilia A

- Hemophilia B

Hemophilia A, the classic and well form of disease caused by factor VIII deficiency though this form is a rare, inherited congenital bleeding disorder that causes a complex of symptoms, such as:

- Prolonged bleeding

- Easy bruising.

Hemophilia A is a disease of males, though it may occur in women. In most cases (35%), there is no family history and the condition is the result of an individual-spontaneous gene mutation. All races are equally affected.

Hemophilia A is a challenging condition for individuals forcing them for huge life modifications. Treatments for hemophilia A are widely and globally available, medicaments are released depending on the severity of symptoms.

Hemophilia A largely requires self-care and an ongoing support from a doctor or healthcare team.

Hemophilia B (Christmas disease) a very rare bleeding disorder causing symptoms like: 

- Prolonged bleeding

- Easy bruising

This disease is due to factor IX deficiency, a less common form than hemophilia A, affecting about 4000 Americans 2013, or ~20% of people with hemophilia.

Christmas disease is an inherited-congenital blood disorder due to factor IX deficiency (a protein necessary for blood to clot). However, just as all Hemophilia we rarely find any family history of hemophilia (less than 35%). And it's well-known that this condition mostly occurs in the second period of life (group of people older than 25 years old) as a result of a spontaneous gene mutation.

Christmas disease is a real challenge for patients suffering of it.

Treatments for hemophilia B mainly depends on the severity of symptoms. And just as Hemophilia A, Christmas disease requires self-care and an ongoing support from a doctor or healthcare team.

Reading and understanding hemophilia can really help make living with the disease easier.

Article Source: [http://EzineArticles.com/?Hemophilia---Orthodox-Medicine&id=8265628] Hemophilia - Orthodox Medicine

Milder Forms Of Hemophilia Do Not Involve Spontaneous Bleeding

Bleeding disorder that slows the blood clotting process Hemophilia. People suffering from this condition suffer from bleeding following surgery, having a tooth pulled and injury. The problem of heavy bleeding occurs in severe cases of hemophilia after minor trauma or even in the absence of injury. Bleeding into the Joints, muscles, brain, or other internal organs, all these problem can lead to serious complications. Milder forms of hemophilia do not involve spontaneous bleeding, and the condition may not become apparent until abnormal bleeding occurs following surgery or a serious injury.

Hemophilia A is the major types of this condition and is also known as classic hemophilia. And hemophilia B is the condition which is also known as Christmas disease. All these type above mentioned have very similar signs and symptoms. These types of hemophilia is caused by mutations in different genes. Person suffering from hemophilia B experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty. Acquired hemophilia is another form of the disorder that is not cause by inherited gene mutations. It is featured by abnormal bleeding into the skin, muscles, or other soft tissues, usually beginning in adulthood.

Fot the treatment of excessive or heavy bleeding in the patients with hemophilia during or after tooth extractions there are various medicine are available in the market. Among all the medicines available the best medicine for excessive or heavy bleeding in the patients with hemophilia during or after tooth extractions is Cyklokapron. Cyklokapron is a prescription medicine. The main ingredient if Cyklokapron medicine is Tranexamic. This medicine is available in form of tablets by generic name. As it is a prescription medicine so it should be taken as prescribe by the doctor.

Before taking this medicine you should know full information about the medicine in order to avoid any serious side effect. If the person is allergic to this medicine or to its ingredient he should not use this medicine as it may lead to serious side effect. Person taking this medicine should get his eye check up regularly. Cyklokapron should be used cautiously in old aged patients as they are more sensitive to its side effects. People who are suffering from the problem of kidney diseases and blood problems should not take Cyklokapron medicine without the doctors advice as they might need a dosage adjustment. Use of this medicine is not recommended for pregnanat and breast feeding mother as use of this medicine in pregnant and breast feeding mother may harm the health of unborn baby or nursed child.

The dosage recommended for Cyklokapron medicine is 2 to 4 times a day or as directed by your doctor. The medicine should be used as prescribe by the doctor for better result. If you are taking any prescription, non prescription and herbal medicine you should inform your doctor before taking Cyklokapron. This medicine should be taken with full glass of water. Store this medicine at room temperature, at dry place, away from light, heat and moisture. Keep all the medicine away from the reach of the children and pet.

Article Source: http://www.articlesbase.com/medicine-articles/milder-forms-of-hemophilia-do-not-involve-spontaneous-bleeding-4848178.html

Author: John Smith

Hemophilia in kids: Causes, Symptoms and Diagnosis

Kids indulge in different activities and play almost all day round. Getting bruises, cuts or wounds is quite expected and normal. However, there are some kids who can not easily recover from even the basic wounds. The reason behind this could be hemophilia. The question now arises, What is hemophilia? It is a disorder related to the clotting process. To understand this, one must first understand how clotting takes place.

Whenever, there is a cut on the body, the platelets get released and fill up the wound. This also activates proteins known as clotting factors, which are vital in the process of clotting. Blood contains twelve such factors, denoted by roman numerals from I-XII. However, not every person has all the twelve factors. Some people witness deficiency of clotting factors VIII, while some lack in clotting factor IX. The ones who have deficiency of factor VIII suffer from hemophilia A, while the ones having lack of IX factor suffer from hemophilia B. most of the people are diagnosed with hemophilia A.

Symptoms

While the signs and symptoms of this bleeding disorder depend on the amount of deficiency, if the extent of bleeding is severe, babies may even witness bruises while crawling. The bruises might develop at stomach, back or even chest. This could give painful sensations to the child due to which child may not even feel like walking. In most of the cases, bleeding happens in joints and muscles , which if goes recurrent can cause damage to the joints.

There are other signs as well that could help parents to know that the child is suffering from a bleeding disorder. Some of these signs are:

1. frequent cases of bleeding nose

2. occurrence of blood in the urine

3. excessive bleeding after tooth extraction or some other surgery

Diagnosis

In many cases, children are diagnosed with hemophilia in the first six months of life. This is because it is difficult for them to sustain any injury that could cause bleeding. However, if the disorder is diagnosed at a later period of time, it is usually done using:

1. Doctor may look out for certain pattern of bruises. For instance, if the bleeding always occurs into the joint, it could be a sign of hemophilia.

2. It can also be diagnosed with the help of blood tests, such as CBC: Complete Blood Count.

Once diagnosed, the treatment of this disorder lies in infusing the deficient clotting factor into the body of the patient.

Article Source: http://www.articlesbase.com/health-articles/hemophilia-in-kids-causes-symptoms-and-diagnosis-6576679.html

Blood Management for Treatment of Hemophilia and other Bleeding Disorders

Bleeding disorders are serious conditions that affect a large number of people around the world. Hemophilia alone affects nearly 20,000 people in the United States and more than 400 children are born each year with the disorder. Severe cases of hemophilia occur almost predominantly in men; women can still be carriers of the gene that causes hemophilia, but only develop mild forms of the bleeding disorder.

Other forms of bleeding disorders include:

Acquired platelet function defects 

Congenital platelet function defects 

Congenital antithrombin III deficiency 

Congenital protein C or S deficiency 

Disseminated intravascular coagulation (DIC) 

Drug-induced immune thrombocytopenia 

Factor II deficiency 

Factor V deficiency 

Factor VII deficiency 

Factor X deficiency 

Factor XII 

Idiopathic thrombocytopenic purpura (ITP) 

Von Willebrand\'s disease 

Bleeding disorders can result from a number of different causes and can be either inherited or acquired. The most common element of these disorders is a lack of the blood parts responsible for clotting (platelets). The result is excessive or heavy bleeding that takes longer for the body to control.

Blood Transfusions as Treatment for Hemophilia -

In the first half of the 20th century, it was common for hemophilia patients and patients with other clotting disorders to be treated with blood transfusions. The process initially involved the transfusion of whole blood or frozen plasma. This was a laborious process, requiring extended hospital stays for each treatment. 

During the 1970s and 80s, the specific clotting factors in the blood became available in more convenient, concentrated forms. Since the clotting factors were the only parts of the blood that hemophiliacs and other patients with bleeding disorders required from the whole blood or plasma, blood transfusions were no longer necessary.

Unfortunately, whether acquired from blood transfusions or through concentrated plasma extracts, the needed platelets still had to come from donor blood banks. By 1987, it became evident that an alarming number of hemophiliac and other bleeding disorder patients had become infected with hepatitis B, hepatitis C, and HIV (the virus that causes AIDS) due to contaminated donor blood.

Although major strides have been made since the late 1980s to improve the safety of donor blood, there are still a number of risks associated with receiving donated blood parts through blood transfusions or other methods. Patients with hemophilia and other bleeding disorders are at risk for any blood borne pathogen, allergic reactions and a number of other complications that can result from receiving donor blood parts or the transfusion process itself.

Blood Management for Treating Hemophilia -

The advent of bloodless medicine, including bloodless surgery and a substantial list of blood management techniques, has provided new alternatives for treating hemophilia and other bleeding disorders. The field of bloodless medicine involves a number of different techniques and new technologies that can minimize the loss of blood during major surgeries. Fortunately for hemophiliacs and patients with similar bleeding disorders, many of the fundamentals and techniques used in blood management can be applied to the treatment of these diseases. 

One such technique involves a gene modified bone marrow transplant. The patients own bone marrow is removed and the stem cells contained in it are treated with Factor VIII - a clotting factor, which is placed in the platelets. The modified bone marrow is transplanted back to the patient, who is now able to produce blood platelets retaining the essential clotting mechanisms that stop internal and external bleeding.

For people suffering from hemophilia and other bleeding disorders, blood management treatments such as these do more than simply eliminate the need for a potentially risk blood transfusion. These new kinds of treatments also have the potential to allow patients to lead a more 'normal' life, without frequent hospital visits. Some hemophiliacs require frequent blood transfusions - as many as three per week. Newer treatments utilizing blood management techniques and research have the potential to drastically reduce treatment times. 

Contact your local hospital or healthcare system for more information about blood management and any bloodless medicine programs that might be available near you.

Article Source: http://www.articlesbase.com/diseases-and-conditions-articles/blood-management-for-treatment-of-hemophilia-and-other-bleeding-disorders-3565029.html

Author: Norman A. Smyke Jr, MD

About the Author

Norman A. Smyke Jr, MD, is a board certified specialist in Anesthesiology and is the director of the Center for Blood Conservation at Grant. Dr. Smyke oversees the first bloodless medicine program in Columbus, Ohio and outlying areas to provide formally recognized blood management services, including bloodless surgery options for hemophilia patients. For more information about the CBC at Grant, please visit www.ohiohealth.com.

How to Treat Hemophilia

Hemophilias are a group of disorders, which are among the most common and serious inherited bleeding disorders. Hemophilia is actually a collection of several different genetic disorders passed on by heredity. The two most common types are hemophilia A and hemophilia B. Hemophilia generally affects men. In fact, one third of 10000 men is born with hemophilia A. About 17000 Americans are born with the genetic disease that causes the disease. Globally, an estimated 500000 people are living with a form of hemophilia.

Two main varieties of hemophilia exist. Hemophilia A is responsible for eighty percent of all cases. The genetic disorders responsible for hemophilia A result in low levels or abnormal production of the clotting protein factor VIII (FVIII). Hemophilia B, the second most common form of hemophilia, affects factor IX proteins (FIX) and accounts for almost twenty percent of hemophilia cases.

Hemophilia is genetic disorder that affects over 18,000 people (most of whom are males) in the United States alone (National Heart, Blood, and Lung Institute 2006). Hemophilia is caused by a deficiency in a gene on the X chromosome coding for a specific coagulating factor (National Heart, Blood, and Lung Institute 2006) or the development of antibodies that destroy coagulating factors (Green 2006).

The types of treatment methods available today are plasma-derived products, recombinant coagulating factors, and gene therapy. Patients who develop an immune response to therapy or have acquired hemophilia are extremely difficult to treat (Mannucci 2003). The treatment options for these patients include prothrombin complex concentrates, activated recombinant factor VII therapies, and immunosuppressive drugs.

Patients with hemophilia should receive integrated care as soon as the diagnosis is made to reduce complications of hemophilia. Patients who suffer from mild to moderate hemophilia A will benefit with the use of intravenous DDAVP or intranasal DDAVP. Factor VIII replacement remains the mainstay of therapy for patients with hemophilia A for minor and major bleeding, whether it is plasma-derived or recombinant. The availability of factor VIII concentrates that are stable in home refrigerators have lead to the development of home care programs. Such programs have resulted in improved preservation of joint function. Hemophilia B is treated with purified factor IX for major and minor hemorrhages.

Hemophilias Treatment and Prevention Tips 

1. Gene therapy is useful treatment of this condition.

2. Aminocaproic acid is commonly used for oral bleeding.

3. Plasmapheresis may help reduce the antibody load in those patients.

In general, the treatment of hemophilia for moderate and severe patients is either a plasma-derived concentrate, and we'll talk about that in some detail, or now available for both VIII and IX deficiency, recombinant factor VIII or factor IX concentrates. The benefits of gene cloning. These concentrates of either VIII or IX are extremely effective and if I don't leave you clearly with this message, there really is no doubt about their efficacy and currently in this day and age, they are extremely safe.

Antifibrinolytic Therapy.

Antifibrinolytic therapy is used to stabilize a clot by inhibiting the normal process of clot lysis by the fibrinolytic system. It is, therefore, very useful ancillary treatment in patients with hemorrhagic disorders. These agents provide important adjunctive therapy for the prevention or treatment of oral hemorrhage because saliva is a rich source of fibrinolytic enzymes. Two drugs are available: (1) epsilon aminocaproic acid (EACA) (Amicar) and (2) tranexamic acid (Cyklokapron). 

Article Source: http://www.articlesbase.com/diseases-and-conditions-articles/how-to-treat-hemophilia-362623.html

Author: peterhutch

Hemophilia Definition

Hemophilia refers to a group of bleeding disorders in which there is a deficiency of one of the factors necessary for coagulation of the blood. Although the symptomatology is similar despite the missing factor, the identification of specific factor deficiencies has allowed definitive treatment with replacement agents. The two most common forms of the disorder are classic hemophilia (hemophilia A or factor IX deficiency). The following discussion is primarily concerned with the classic form, which accounts for about 75% of all cases.

A major feature of hemophilia is that its expression varies markedly in the degrees of bleeding severity. Hemophilia is generally classified into three groups according to the severity of factor deficiency. 

1. Severe defects with less than 1% of the normal amount of factor; affected individuals bleed spontaneously or from minor trauma and literally may die from exsanguinations 

2. Moderate defects with levels of 1% to 5% affected individuals usually bleed after some type of trauma but do not bleed spontaneously 

3. Mild defects with levels ranging between 5% and 25% affected individuals manifest bleeding tendencies after they sustain a serious injury or undergo surgery, such as dental extraction or tonsillectomy.

In about 80% of cases of hemophilia, the inheritance is demonstrated as an X-linked recessive disorder. The most frequent pattern of transmission is between an unaffected male and a trait-carrier female with improved treatment for persons with hemophilia, it is important to consider the results of mating between an affected male and normal female or a carrier female. For example, the mating of an affected male with a carrier female results in a 1:4 chance of producing either an affected son or daughter, a carrier daughter, or a normal son. This is one of the few ways in which a female can become a hemophiliac.

Other reasons for female expression of the disease include 

1. A "symptomatic" earner of classic hemophilia with a moderate defect of factor VIII 

2. a phenotypic female who has inherited the recessive gene for hemophilia but lacks the second X chromosome, as in Turner's syndrome 

3. A female with an autosomal dominant transmitted form of factor VIII deficiency, such as von willebrands's disease 

4. A female with severe factor deficiency whose parents are normal or chromosomal aberration.

Pathophysiology 

In hemophilia A the factor VIII molecule is present but is defective in its clotting function. Factor VIII-related antigen (FVIIIR:Ag) is normal. In hemophilia B there may be a defect or a deficiency of factor IX.

Clinical manifestations 

The effect of hemophilia is prolonged bleeding anywhere from or in the body. With severe factor deficiencies hemorrhage can occur as a result of minor trauma, such as after circumcision, during loss of deciduous teeth, or as a result of a slight fall or bruise.

Subcutaneous and intramuscular hemorrhages are common, Hemarthrosis, bleeding into the joint cavities, especially the knees, ankles, and elbows, is the most frequent site of internal bleeding and often results in bone changes and consequently crippling, disabling deformities, spontaneous hematuria is not uncommon, Epistaxis mau occur but is not as frequent as other kinds of hemorrhage.

Bleeding into the tissue can occur anywhere but is serious if it occurs in the neck, mouth, or thorax, since the airway can become obstructed, Intracranial hemorrhage can result in fatal consequences, although this occurs less frequently than expected because the brain tissue has a high concentration of thromboplastin. Hemprrhage anywhere along the gastrointestinal tract can lead to obstruction, melena and vomiting with blood. Hematomas in the spinal cord can cause paralysis.

Petechiae are uncommon in persons with hemophilia because repair of small hemorrhages is dependent on platelet function, not on blood-clotting mechanisms

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Hemophilia B

What are the future of treatments for hemophilia?

The future for our friends living with Hemophilia disorder is very exciting.

"Hemophilia may be "the royal disease," but for most commoners, it's only just a drag.

Even if the sufferer can avoid major blood loss, but the unseen internal bleeding can cause long-term damage to the joints and organs.

Yet the last 40 years have seen several changes in hemophilia treatment, and Biogen Idec (BIIB) is preparing an FDA filing for a new drug that it says will bring another one. "Whenever these products are approved, they will represent a real benefit to patients for the first time in 15 years," Biogen R&D head Douglas Williams told IBD.

For the last few decades, the hemophiliacs have been treated by infusion with blood products which containing the missing clotting factors (factor 8 for hemophilia A and factor 9 for B). These used to be derived from human plasma, but this turned out to carry a very serious risk of disease.

For that reason, drug makers more recently developed "recombinant" products created from the animal or artificial sources. In hemophilia A, which is a roughly $5 billion market, the leading drug is Baxter International's (BAX) Advate; other recombinant products include Bayer's (BAYRY) Kogenate and Pfizer's (PFE) Xyntha. Filtering process for plasma has also improved, so Baxter also still sells its plasma product Hemofil.

Prophylactic Treatment

A less number of patients develop antibodies, or "inhibitors," to these products.

In the clinical testing, more than one drug candidate has been sunk when too many patients developed inhibitors. Novo Nordisk (NVO), however, has developed a product called NovoSeven, which successfully treats many patients who have inhibitors to factor 8 products.

Safety improvements also led to the rise of prophylactic treatment for hemophilia. Patients used to just get treated in response to bleeding episodes, but many patients nowadays infuse themselves every other day to prevent bleeding episodes from occurring in the first place. Only about 35% of adult patients do this, however, because it's a tough regimen. This isn't just a little injection like a diabetic with insulin; patients have to find a vein for an IV infusion that can take around an hour. So, much of the current pipeline is focused on making the IV regimen easier, particularly by making it less frequent.

That's where Biogen's long-acting recombinant factor 8 fusion protein, or rFVIIIFc, comes in. In the phase-three results released Oct. 31, 30% of subjects successfully prevented bleeding episodes by infusing just once every five days. None developed inhibitors. Despite the improvement on the existing methods, ISI Group analyst Mark Schoenebaum was underwhelmed. "However, we estimate that 50% of the patients got to at least every four days based on the reported 3.5-day median." Biogen also reported great results for the drug in hemophilia B, which is less than a $1 billion market but one with much less competition. That market is dominated by Pfizer's BeneFix.

Demand Is Big Question

A very big question, however, is just how many patients are clamoring for a new drug. The Doctors who work with hemophiliacs say the bad experience with plasma products left many of them wary of new drugs. But Dr. Amy Shapiro, head of the Indiana Hemophilia & Thrombosis Center, says younger patients don't have those memories. They could also benefit from a longer-acting product, because it's more harder to find a vein in a child patient. "They may require a venous-access device to achieve the number of infusions they need," Shapiro told IBD. "That in itself is a surgery that can have side effects and complications. If we can avoid that by having longer-acting products and get more patients on prophylactics on peripheral venopuncture instead of using a device, that would be really a great achievement."

Article Source: http://www.articlesbase.com/diseases-and-conditions-articles/what-are-the-future-of-treatments-for-hemophilia-6386220.html

Author: adammark1

Hemophilia A

Hemophilia - A General Examination to the Incurable Bleeding Disease

Hemophilia disease refers to a group of diseases. Each of these diseases affects the body's ability to clot or coagulate blood. Basically, if a hemophiliac is cut or suffers from internal bleeding, the body is unable to clot and stop the bleeding.

If you're curious about hemophilia and want to learn more about it, please read on.

Root Causes of Hemophilia

Hemophilia is a genetic disease. There are three types of hemophilia - Hemophilia A, which is caused by non-functioning clotting Factor VII, is the most common; Hemophilia B is caused by non-functioning clotting Factor IX; and Hemophilia C, which is caused by non-functioning clotting Factor XI.

Typically, hemophilia affects males. Women are usually just carriers. If a father has hemophilia, he won't pass it to his son, but he will almost always pass it to a daughter. If a mother is a hemophilia gene carrier, there is a 50 percent chance that she will pass the gene on to her child. It's important to note that hemophilia is relatively rare.

Treating Hemophilia Disease

Hemophilia does not have a cure. That said, the disease is typically controlled by adding the missing clotting factors to the patient's blood. This is called prophylactic treatment because it's designed to prevent bleeding incidents. Some hemophiliacs may begin to resist the antibodies of these clotting factors, so animal derivatives must then be used.

In other treatment news, there is new a drug that was recently approved which has been dubbed an anti-hemophiliac option. It's genetically engineered from Chinese hamsters and believed to help the body begin to create the needed factors.

Usually, if a patient is undergoing prophylactic treatment, it's an ongoing process that continues on a weekly or monthly basis throughout the course of his life. However, some patients opt for on-demand service, meaning they only receive clotting agents when bleeding occurs. This is the more affordable treatment method most often chosen by those living in the U.S. without health insurance.

In areas or countries where health care is covered by the state, patients can typically attend care centers designated for hemophiliac care. They are then assigned a hematologist, nurse, physiotherapist and social worker to help them with their treatments and continuation of care.

Alternative Care for Hemophiliacs

Some people believe that hemophilia can be controlled through hypnosis. They state it can reduce the amount of severe bleeds and help control bleeding once it starts. However, this has never been proven in a clinical setting and has not yet been subject to medical review.

Other methods include ingesting certain herbs, like scotch broom or grape seed extract, which are believed to strengthen the blood vessels. Again, there is no clinical evidence that suggest these particular herbs are an effective or even preventive remedy for hemophilia disease.

Speak first with your doctor, however, before attempting such an option. Clinically unproven options can certainly generate an exciting ray of hope when combined with persuasive anecdotal data. But your health is too precious - and for hemopheliacs, too precarious - to venture very far outside established medical norms without convincing evidence of consistent success.

Article Source: http://www.articlesbase.com/health-articles/hemophilia-a-general-examination-to-the-incurable-bleeding-disease-600425.html

Author: Trevor Price

About the Author

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What is Hemophilia

Know About Hemophilia - You might have heard of people with different kind of disorders like allergies, Behavioral disorders, chromosomal disorder and many other. Bleeding disorder(hemophilia) is one of the types of chronic disorder that we will discuss here in this article. But, before that, let us know what is disorder? And then what is hemophilia?

Disorder is when something is not in order or when something is not as it is suppose to be. For example, A person suffering from sleeping disorder may find it difficult to sleep or may sleep most of the time. In this case the sleep is not in regular or normal. Similarly, few people may have bleeding disorder called hemophilia.

What is hemophilia?

It is a bleeding disorder in which it becomes difficult to stop bleeding during any injury, whether internal or external. In this, blood does not clot in a normal time or take longer time to clot. That is, the person has poor blood clotting. It may occur at a regular intervals or may be caused more often in severe cases.

When it takes more time for blood to Coagulate or to clot, then the person is said to have bleeding disorder. This happens in the person who have low platelet counts or proteins. As the platelets, proteins and other clotting factors react together to form blood clot.

Some of the various symptoms of hemophilia are excessive or easy bleeding, nose bleedings etc. some of the risks involved in this disorder are vision loss when bleed into the eye, anemia, psychiatric problems or even death, if, blood is lost in huge amount.

Causes of hemophilia are liver disease, bone marrow problem, blood cancer, low immune system, antibodies, excessive use of medicines like aspirin, which is actually used in case of breaking the unusual blood clots.

This disorder is found mostly in men. The reason behind this is that there is a difference between a male chromosomes and female chromosomes. Wherein, women have a pair of X chromosomes, whereas, men have one X and the other Y. Hence, females rarely face this disease, whereas, she may acquire it by a defective gene or by mutation. This disorder can be detected during childhood itself.

One should get this disorder diagnosed as early as possible and should get its treatment done. One can either opt for demand therapy, which is done on demand, when bleeding occurs. The other procedure is of Replacement therapy, which is done at regular interval. If this disorder is not treated then one may have joints and muscle pain and redness on joints.

There are some non-profitable foundations that work to help people suffering from this disorder. You can search for them online. Hemophilia Non-Profit Donations are the donation made to help people suffering from this disorder. One can donate to help people and help them live a happy life.

Article Source: http://www.articlesbase.com/diseases-and-conditions-articles/know-about-hemophilia-6691935.html

Author: adammark1